Oxidative Stress in Cancer Biology and Therapy by Douglas R. Spitz download in pdf, ePub, iPad
These metals are thought to induce Fenton reactions and the Haber-Weiss reaction, in which hydroxyl radical is generated from hydrogen peroxide. Oxidative stress also plays a role in the ischemic cascade due to oxygen reperfusion injury following hypoxia. This action catalyzes production of reactive radicals and reactive oxygen species.
Overall, observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked. For example, in Alzheimer's patients, peroxidized lipids and proteins accumulate in lysosomes of the brain cells. For example, meta- tyrosine and ortho- tyrosine form by hydroxylation of phenylalanine. Lipid-soluble and similar in reactivity to hypochlorous acid.
One of the most important classes of these are the quinones. The amino acid methionine is prone to oxidation, but oxidized methionine can be reversible. Less well studied but probably just as important enzymatic antioxidants are the peroxiredoxins and the recently discovered sulfiredoxin. Other enzymes that have antioxidant properties though this is not their primary role include paraoxonase, glutathione-S transferases, and aldehyde dehydrogenases. Lipid-soluble and highly reactive.
Formed by radical reactions with cellular components such as lipids and nucleobases. Produced in the presence of oxygen by radical addition to double bonds or hydrogen abstraction. Oxidative stress is likely to be involved in age-related development of cancer.
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