Protein-Nanoparticle Interactions by Masoud Rahman download in pdf, ePub, iPad
Exposure to nanomaterials for humans may be accidental, for example occupational exposure, or intentional, for example in the use of nano-enabled consumer products. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake. Each of these proteomes represents unique environments and has specific properties with respect to their protein composition, enzymatic activities, pH, ion composition etc. Abstract Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity.
Nevertheless, our knowledge about the bio-compatibility and risks of exposure to nanomaterials is limited. Nanoparticle protein corona Proteins are polypeptides with a defined conformation and carry a net surface charge depending on the pH of the surrounding medium. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. Particularly in the bio-medical field, the use of nano vaccines and nano drugs are being intensively researched.